Publications by authors named "D Northfelt"
Article Synopsis
- AI/AN populations have the highest cigarette smoking rates in the U.S., but past efforts haven't focused enough on maintaining cessation or pregnancy-related behaviors.
- Researchers aim to conduct a mixed-methods study to identify effective smoking cessation strategies.
- A community-engaged approach will involve qualitative interviews with AI/AN individuals and counselors, leading to a larger survey to develop and test new intervention methods for reducing smoking rates in this community.
Purpose: Contrast-enhanced mammography (CEM) and magnetic resonance imaging (MRI) have shown similar diagnostic performance in detection of breast cancer. Limited CEM data are available for high-risk breast cancer screening. The purpose of the study was to prospectively investigate the efficacy of supplemental screening CEM in elevated risk patients.
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- Tumor immune infiltration and blood immune signatures are important for predicting outcomes in breast cancer, but their link to response from neoadjuvant chemotherapy (NAC) hasn't been well studied.
- In a study of 126 breast cancer patients, various immune cell populations in their blood were analyzed to determine if these profiles could predict how well patients would respond to NAC.
- The findings indicated that specific immune cell types (like myeloid cells in triple-negative and T cells in hormone receptor-positive breast cancer) correlated with treatment responses, while those in HER2-positive cancer showed no significant associations.
Purpose: Automated scalp cooling (ASC) is available to patients undergoing chemotherapy for breast cancer to decrease chemotherapy-induced alopecia. This study sought to elucidate patient and chemotherapy nursing perspectives on the ASC experience.
Methods: This is a survey-based study of chemotherapy nursing staff and patients with breast cancer regarding perceived efficacy, side effects, administration, support, and overall opinions of ASC.
Endocrine therapies (ET) with cyclin-dependent kinase 4/6 (CDK4/6) inhibition are the standard treatment for estrogen receptor-α-positive (ER+) breast cancer, however drug resistance is common. In this study, proteogenomic analyses of patient-derived xenografts (PDXs) from patients with 22 ER+ breast cancer demonstrated that protein kinase, membrane-associated tyrosine/threonine one (PKMYT1), a WEE1 homolog, is estradiol (E2) regulated in E2-dependent PDXs and constitutively expressed when growth is E2-independent. In clinical samples, high PKMYT1 mRNA levels associated with resistance to both ET and CDK4/6 inhibition.
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