E2F1 copy number variations in germline and breast cancer: a retrospective study of 222 Italian women.

Background: Breast cancer is the most common neoplasia among women in developed countries. The risk factors of breast cancer can be distinguished in modifiable and unmodifiable factors and, among the latter, genetic factors play a key role. Copy number variations (CNVs) are genetic variants that are classified as rare when present in less than 1% of the healthy population.

Clinical Utility of Plasma KRAS, NRAS and BRAF Mutational Analysis with Real Time PCR in Metastatic Colorectal Cancer Patients-The Importance of Tissue/Plasma Discordant Cases.

Background: Tumor tissue (T) mutational analysis represents the standard for metastatic colorectal cancer (mCRC); however, circulating tumor DNA (ctDNA) detected by liquid biopsy in plasma (PL) can better represent tumor heterogeneity.

Methods: mCRC patients undergoing standard first-line chemotherapy with known T-KRAS/NRAS/BRAF status were enrolled in the present prospective study. PL mutations were assessed within 2 weeks before chemotherapy start with real time PCR and correlated with T status and Progression free survival (PFS).

A Combined Approach of Field Data and Earth Observation for Coastal Risk Assessment.

The traditional approach for coastal monitoring consists in ground investigations that are burdensome both in terms of logistics and costs, on a national or even regional scale. Earth Observation (EO) techniques can represent a cost-effective alternative for a wide scale coastal monitoring. Thanks to the all-weather day/night radar imaging capability and to the nationwide acquisition plan named MapItaly, devised by the Italian Space Agency and active since 2010, COSMO-SkyMed (CSK) constellation is able to provide X-band images covering the Italian territory.

Performance Analysis of Satellite Missions for Multi-Temporal SAR Interferometry.

Multi-temporal InSAR (MTI) applications pose challenges related to the availability of coherent scattering from the ground surface, the complexity of the ground deformations, atmospheric artifacts, and visibility problems related to ground elevation. Nowadays, several satellite missions are available providing interferometric SAR data at different wavelengths, spatial resolutions, and revisit time. A new and interesting opportunity is provided by Sentinel-1, which has a spatial resolution comparable to that of previous ESA C-band sensors, and revisit times improved by up to 6 days.