Publications by authors named "D Niedospial"
The impact of APOE4 on neurological symptoms after exposure to K. brevis neurotoxin.
Environ Toxicol Pharmacol
December 2024
Introduction: The harmful alga Karenia brevis (K. brevis) releases brevetoxins (PbTx) that cause respiratory and neurological symptoms. The apolipoprotein E (APOE) ε4 allele has been linked to poor neurological outcomes after exposure to environmental toxicants.
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- A study found that changes in the brain entorhinal cortex (EC) and specific blood lipids are linked to Alzheimer's disease (AD) in individuals with the apolipoprotein E ε4 genetic variant.
- Analysis of brain imaging and lipid profiles revealed that ε4 carriers with mild traumatic brain injury (mTBI) had thicker left ECs, but repeated mTBIs reduced right EC thickness.
- The research highlights the need for further investigation into the relationship between ε4, mTBI, and specific blood lipid ratios as potential biomarkers for early detection of AD in affected individuals.
Introduction: Exposure to nerve agents, pyridostigmine bromide (PB), pesticides, and oil-well fires during the 1991 Gulf War (GW) are major contributors to the etiology of Gulf War Illness (GWI). Since the apolipoprotein E (APOE) ε4 allele is associated with the risk of cognitive decline with age, particularly in the presence of environmental exposures, and cognitive impairment is one of the most common symptoms experienced by veterans with GWI, we examined whether the ε4 allele was associated with GWI.
Methods: Using a case-control design, we obtained data on APOE genotypes, demographics, and self-reported GW exposures and symptoms that were deposited in the Boston Biorepository and Integrative Network (BBRAIN) for veterans diagnosed with GWI (n = 220) and healthy GW control veterans (n = 131).
In southwest Florida, Karenia brevis (K. brevis) blooms occur frequently, can be very intense and persist over several years. Individuals living in coastal communities around the Gulf of Mexico are particularly vulnerable to brevetoxins released by K.
View Article and Find Full Text PDFBackground: There is limited data regarding adaptive immunity in older persons with Multiple Sclerosis (MS).
Objective: The aim of the present study was to quantify adaptive immune cells in younger (age less than 50) and older (age greater than 50) with MS in the context of clinical parameters (EDSS, 25-foot walk, SDMT). Subjects were either Untreated (no MS medications in 6 months), taking Injectables (interferons or glatiramer acetate), or Other approved MS treatments.