Publications by authors named "D Netuka"
Rosette-forming glioneuronal tumors (RGNTs) with FGFR1 tyrosine kinase domain internal tandem duplication (FGFR1 ITD) is exceedingly rare, with only a few cases reported in the literature. Hereby we present a case of a tumor with RGNT morphology occurring in area of septum pellucidum of 43-year-old male. The tumor showed FGFR1 ITD, no PIK3CA, PIK3R1 or NF1 alterations and inconclusive methylation profile with match for class of "low-grade glial/glioneuronal/neuroepithelial tumors".
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- Glioblastoma is the most common and aggressive primary brain tumor, making diagnosis difficult due to its genetic variability and poor prognosis.
- A complex case study utilized multiple cytogenomic methods to identify key genetic markers, revealing classical glioblastoma characteristics and distinct pathological clones.
- The study suggests an integrated approach for diagnosis, focusing on detecting genetic alterations to potentially improve patient outcomes in terms of diagnosis, prognosis, and treatment predictions.
Introduction: Central nervous system lymphoma poses significant diagnostic challenges, with stereotactic biopsy being the gold standard for diagnosis. Intraoperative magnetic resonance imaging and intraoperative histological examination are utilized to enhance biopsy yield, yet their comparative efficacy remains unclear.
Research Question: This study aims to compare the diagnostic yield of intraoperative magnetic resonance imaging and intraoperative histological examination in stereotactic brain biopsies for central nervous system lymphoma.