Publications by authors named "D Negre"
Article Synopsis
- Brown seaweeds are vital to coastal ecosystems, but they are threatened by climate change, prompting a detailed genetic study.
- The research traced the evolutionary history of brown algae, highlighting significant gene families and metabolic pathways related to their adaptation and functional diversity.
- Findings also indicated that the integration of large viral genomes has played a crucial role in shaping the genetics and traits of brown algal species over time.
Cancer remains a leading cause of death worldwide, but immunotherapies hold promises to cure it by awaking the patient's immune system to provide long-term protection. Cell therapies, involving the infusion of immune cells, either directly or genetically modified, are being developed to recognize and destroy cancer cells. Here, we explored the potential of a new synthetic circuit to reprogram B cells to cure cancers.
View Article and Find Full Text PDFIn recent years, genome sequencing of filamentous fungi has revealed a high proportion of specialised metabolites with growing pharmaceutical interest. However, detecting such metabolites through in silico genome analysis does not necessarily guarantee their expression under laboratory conditions. However, one plausible strategy for enabling their production lies in modifying the growth conditions.
View Article and Find Full Text PDFEngineering B cells with customized therapeutic responses using a synthetic circuit.
Mol Ther Nucleic Acids
September 2023
The expansion of genetic engineering has brought a new dimension for synthetic immunology. Immune cells are perfect candidates because of their ability to patrol the body, interact with many cell types, proliferate upon activation, and differentiate in memory cells. This study aimed at implementing a new synthetic circuit in B cells, allowing the expression of therapeutic molecules in a temporally and spatially restricted manner that is induced by the presence of specific antigens.
View Article and Find Full Text PDFContext: Mammalian target of rapamycin complex 1 (mTORC1) is an essential sensor that regulates fundamental biological processes like cell growth, proliferation and energy metabolism. The treatment of disease by sirolimus, a mTORC1 inhibitor, causes adverse effects, such as female fertility disorders.
Aims: The objective of the study was to decipher the reproductive consequences of a downregulation of mTORC1 in the hypothalamus.