Demographic parameters of Pachycrepoideus vindemiae (Hymenoptera: Pteromalidae) reared on Drosophila suzukii (Diptera: Drosophilidae), Ceratitis capitata (Diptera: Tephritidae), and Anastrepha fraterculus (Diptera: Tephritidae) puparia.

Pachycrepoideus vindemiae (Rondani) is a solitary generalist pupal ectoparasitoid that parasitizes dipterans of various families and genera. This study aimed to evaluate Anastrepha fraterculus (Wiedemann), Ceratitis capitata (Wiedemann), and Drosophila suzukii (Matsumura) to determine the best host for the development and mass production of parasitoid P. vindemiae in the laboratory.

Combination of locoregional radiotherapy with a TIM-3 aptamer improves survival in diffuse midline glioma models.

Pediatric diffuse midline gliomas (DMG) with altered H3-K27M are aggressive brain tumors that arise during childhood. Despite advances in genomic knowledge and the significant number of clinical trials testing new targeted therapies, patient outcomes are still poor. Immune checkpoint blockades with small molecules, such as aptamers, are opening new therapeutic options that represent hope for this orphan disease.

Different Protein Sources of Larval Diet on the Rearing of Anastrepha fraterculus (Diptera: Tephritidae): Biological and Nutritional Analyses.

Anastrepha fraterculus (Diptera: Tephritidae) is considered an important pest in Neotropical countries. The laboratory rearing of this species should reproduce conditions in nature; thus, special attention is required to the nutritional quality of diets for larval development. Protein components (wheat germ) are costly and account for most production costs in lab insect rearing.

Diastereoselective Palladaelectro-Catalyzed Construction of Bromomethyl Morpholines as Key Step To Access Morpholino Homonucleosides.

A synthetic protocol for the preparation of a new class of morpholino homonucleosides in enantiopure form starting from readily available 1,2-aminoalcohols or glycidol has been developed. Key intermediates of the synthetic sequence are 2-bromomethyl morpholines, diastereoselectively achieved from the corresponding alkenols by palladaelectro-catalyzed alkoxybromination of unactivated alkenes. The so obtained bromo derivatives are in turn susceptible to functionalization with nucleic bases for easy access to morpholino homonucleosides.