Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis.

Bromodomain-containing protein 4 (BRD4) has emerged as a promising therapeutic target in prostate cancer (PCa). Understanding the mechanisms of BRD4 stability could enhance the clinical response to BRD4-targeted therapy. In this study, we report that BRD4 protein levels are significantly decreased during mitosis in a PLK1-dependent manner.

[What is social sciences' contribution in the context of health crises and emerging risks? An anthropologist's perspective].

What can the social science contribute during a public health crisis? Reflecting on this question, we turn to the medical anthropologist David Napier, who has developed research tools for understanding the complex drivers of health vulnerability and resilience. Interviewed by Nolwenn Bühler, he shares his vision of the Covid-19 crisis, and the role social sciences should be playing in understanding why populations either trust or mistrust policymakers. In that a crisis, by definition, involves demands on limited resources, social trust is itself put to the test.

Drawing a pandemic vulnerabilities' map: The SoNAR-global Vulnerabilities Assessment digital and its output.

This paper describes the process, advantages and limitations of a qualitative methodology for defining and analyzing vulnerabilities during the COVID-19 pandemic. Implemented in Italy in two sites (Rome and outside Rome, in some small-medium sized municipalities in Latium) in 2021, this investigation employed a mixed digital research tool that was also used simultaneously in four other European countries. Its digital nature encompasses both processes of data collection.