Intradiscal treatment with recombinant human MMP-7 for patients with lumbar disc herniation: A sham-controlled multicenter, single-blind, dose-escalation, single-dose, phase I/IIa study.

Background: This sham-controlled multicenter, single-blind, dose-escalation, single-dose, phase I/IIa study aimed to validate the safety and exploratory efficacy of intradiscal administration of recombinant human (rh) MMP-7 (KTP-001) for patients with lumbar disc herniation.

Methods: The cohort consisted of three groups. Cohort 1 (C1): three patients in the Sham group, three patients in the KTP-001 X-μg group.

Effectiveness of dupilumab treatment against refractory eosinophilic chronic rhinosinusitis.

Background: Eosinophilic chronic rhinosinusitis (ECRS) is a subgroup of chronic rhinosinusitis with nasal polyps (CRSwNP), which is a disease characterized by eosinophilic infiltration of the sinonasal mucosa. Few studies that reported the effect of dupilumab on CRSwNP focused on a single phenotype of CRSwNP, such as ECRS.

Objectives: This study aimed to determine the effectiveness of dupilumab in ECRS with postoperative recurrence.

Impact of residual ethmoidal laminae on dupilumab efficacy following endoscopic sinus surgery in patients with chronic rhinosinusitis: A STROBE analysis.

Aim: This study aimed to investigate the impact of residual ethmoidal laminae after endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).

Materials And Methods: This retrospective cohort included 66 patients with CRSwNP who received 300mg of dupilumab every 2weeks for 16weeks between August 2020 and March 2022. Patients were categorized into the no-lamina or residual-lamina groups based on postoperative sinus computed tomography scans.

The Association of Family and Friend Networks with Appetite: Structural Equation Modeling of the Indirect Effects of Depression among Community-Dwelling Older Adults.

Background: Appetite loss in older adults raises the risk of malnutrition and frailty. The recent emphasis on psychological and social support for appetite loss reveals the importance of robust social networks. Depression is linked to a decline in appetite and social networks.

Relationship between visuospatial working memory and fine and gross motor skills in children with developmental disabilities: a preliminary study.

[Purpose] The relationship between fine and gross motor function and visuospatial working memory in children with autism spectrum disorder remains unclear. This study examined whether visuospatial working memory is associated with gross or fine motor skills in children with developmental disabilities and motor coordination disorders. [Participants and Methods] The study included 30 children with autism spectrum disorder (24 boys and 6 girls; mean age: 9.