CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions.

The complexity of the human brain makes it challenging to understand the molecular mechanisms underlying brain function. Genome-wide association studies have uncovered variants associated with neurological phenotypes. Single-cell transcriptomics have provided descriptions of changes brain cells undergo during disease.

A systemic evaluation of COVID-19 vaccination drives in LICs, LMICs, UMICs, and HICs: Preparedness for future pandemics.

Introduction: The COVID-19 pandemic has significantly impacted global healthcare systems. Vaccination is an effective strategy to battle the disease. Policies and distribution frameworks have varied widely across countries.

Development of Texas's First Chinese American Community Health Worker Certification for Family Health History-Based Cancer Prevention.

To address leading health organizations' calls for public health professionals to adopt family health history (FHH) into their practice, we developed the first community health worker Texas state-certification program focusing on FHH-based cancer prevention for Chinese Americans, for whom cancer is the leading cause of death. The 160-hour program trained 46 Chinese American CHWs to provide FHH-based cancer prevention services for 1129 Chinese Americans. Our program contributes to the establishment of a public health workforce with FHH-based competence and reduces cancer disparities.

Evaluating the Effects of Sugar Shift Symbiotic on Microbiome Composition and LPS Regulation: A Double-Blind, Placebo-Controlled Study.

(1) Background: This study evaluated the effects of BiotiQuest Sugar Shift, a novel probiotic formulation, for its impact on gut microbiome composition and metabolic health in type 2 diabetes mellitus (T2D). T2D is characterized by chronic inflammation and gut microbiome imbalances, yet the therapeutic potential of targeted probiotics remains underexplored. (2) Methods: In a 12-week randomized, double-blind, placebo-controlled trial, 64 adults with T2D received either Sugar Shift or placebo capsules twice daily.