Publications by authors named "D N Szilagyi"
: primary thyroid lymphoma (PTL) is a rare neoplasm, displaying a variety of histological features. It is often a challenge for pathologists to diagnose this tumor. : this study is a retrospective analysis of clinical and pathological characteristics of a group of eleven patients (eight women and three men, mean age 68 years, range 50-80 years) diagnosed with PTL.
View Article and Find Full Text PDFDue to the similarity between the pathomechanism of SARS-CoV-2 infections and hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE), a possibility emerged that C1-INH-HAE may worsen the course of the infection, or that the infection may influence the severity of angioedema (HAE) attacks in C1-INH-HAE patients. Our study aimed to evaluate the effects of the COVID-19 pandemic on the quality of life (QoL) of Hungarian C1-INH-HAE patients, and to survey the acute course of the infection, post COVID symptoms (PCS), vaccination coverage and the side effects of vaccines in this patient population. 93 patients completed our questionnaire between 1st July 2021 and 31st October 2021.
View Article and Find Full Text PDFBackground: In hereditary angioedema (HAE) due to C1-inhibitor deficiency (C1-INH-HAE), bradykinin-mediated submucosal and/or subcutaneous angioedema dominates the clinical picture. The deficiency of C1-inhibitor can lead to the over-activation of the complement system. Complement plays an important role in all types of hypersensitivity reactions.
View Article and Find Full Text PDFArticle Synopsis
- Protein-protein interactions (PPIs) are essential for biological processes and can be applied in areas like drug design and synthetic biology, with coiled-coils used as a model for studying their specificity.
- The development of the next-generation bacterial two-hybrid (NGB2H) method enables faster and more scalable testing of large protein libraries by utilizing next-generation sequencing.
- This research results in the identification of the largest set of orthogonal coiled-coils to date, including fifteen unique interactions, and contributes to a more precise scoring algorithm for predicting coiled-coil interactions.
Article Synopsis
- This study investigated the clinical and pathological characteristics of patients with invasive cutaneous melanomas and aimed to determine the prognostic factors affecting the spread of cancer to lymph nodes.
- A total of 79 patients were reviewed, revealing significant findings such as 58.3% having a Breslow tumor thickness greater than 2 mm and 43.1% experiencing lymph node metastases.
- Key prognostic factors identified included Breslow thickness >2 mm, high Clark level, high mitotic rates, and ulceration, suggesting that even some less aggressive melanomas may still evolve unexpectedly, necessitating careful patient monitoring.