Publications by authors named "D N Sipkin"

Article Synopsis
  • - A highly sensitive HPLC-ESI/MS method was developed for accurately measuring a new antifungal drug, TDZ, using a simplified extraction process from plasma and urine samples.
  • - The method utilized reversed-phase HPLC with a specific column and mobile phase, allowing for effective separation and detection of TDZ with a strong linear response (R=0.999) across two concentration ranges.
  • - This technique was validated with low matrix effects and high recovery rates, and it was successfully used to evaluate the drug's pharmacokinetic parameters after intravenous and oral administration in rats.
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Chlamydia trachomatis infection in college students has not undergone a detailed large-scale evaluation. The authors undertook a cross-sectional study of 4,086 students enrolled on the campuses of California State University, Sacramento, and 3 local community colleges from fall 2000 through spring 2002. They used an outreach screening model to determine the presence of infection by testing urine for chlamydial DNA by polymerase chain reaction.

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Our purpose was to study the peculiarities of changing the hemostasis in children with chronic constipation. In the course of our investigation of hemostasis in children with chronic constipation, we found chronometric hypocoagulation with impairment of internal (XII, XI, IX, VIII) and external (II, V, VII, X) mechanisms of blood clotting, at the base of which is a deficit of vitamin K-dependent factors (II, VII, IX, X) and a slight impairment of the final stage of coagulation. In thrombocytovascular hemostasis, thrombocytopathy demonstrated increased adenosine-5-diphosphate aggregation and suppression of the internal route of fibrinolysis and endotheliosis.

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