Correlation of Antibodies to Neurotransmitters in the Sera of Women with Alcohol Dependence and Depressive Disorders.

Comparative analysis of blood sera from women with alcohol dependence and depressive disorders or from conditionally healthy women revealed reduced level of antibodies to dopamine, norepinephrine, serotonin, glutamate, and GABA in blood serum in women with dysthymic disorder and a depressive episode and their increased content in women with alcohol dependence in combination with depressive disorders.

Role of olfactory reactions, nociception, and immunoendocrine shifts in addictive disorders.

Background And Objectives: Addictive pathology is associated with nervous, immune, and endocrine shifts. Meanwhile, the nature of intersystemic relationship lying beneath addictive disorders remains unclear. The purpose of the study was to identify neuroimmunoendocrine markers of addictive disorders in male subjects defining the nature of their interaction.

[OLFACTORY EEG PATTERNS OF MENTAL AND BEHAVIORAL DISORDERS DUE TO PSYCHOACTIVE SUBSTANCE USE].

The 74 persons, including the 39 persons with mental and behavioral disorders due to psychoactive substance use (PAS) and the 35 persons with subclinical forms of substance use, are examined. The olfactory EEG patterns, differing in narcological patients depending on the range of PAS used, are revealed. EEG markers of olfactory response to isopropanol, thymol and androstenone in combination with emotional evaluation, having hemispheric features, can be diagnostic and differential predictive factors for assessment of predisposition to mental and behavioral disorders due to PAS use.

Cytokine mediated changes of pain sensitivity in predisposition to substance dependence.

Unlabelled: The purpose of study was evaluation of extra and intracellular cytokine production in blood cultures and cytokine-pain relationship at different stages od addiction.

Methods: Classic and multiplex enzyme immunoassay, flow, cytometry, algometry, visual analogue scale were used in 34 abusers, 12 users and 20 control subjects.

Results: Cytokine profile correlated with clinical parameters and pain sensitivity in abusers (mostly IL-6 and IL-1β).

[Autoantibodies to glutamate and GABA in opiate addiction].

Blood serum from 129 patients with opium addiction at different stages of the disease and 63 donors (control group) was examined for the presence of autoantibodies to the exciting and inhibitory amino acids glutamate and GABA. It was shown enhanced production of autoantibodies to glutamate and GABA. Dependence of the level and frequency of detec- tion of autoantibodies to glutamate and GABA on the stage of the disease was revealed.