Publications by authors named "D N Papatsonis"
Detection of postpartum uterine activity with electrohysterography.
Eur J Obstet Gynecol Reprod Biol
December 2023
Objective: Uterine contractions are essential for childbirth, but also for expulsion of the placenta and for limiting postpartum blood loss. Postpartum hemorrhage is associated with almost 25% of the maternal deaths worldwide and the leading cause of maternal death in most low-income countries. Little is known about the physiology of the uterus postpartum, particularly due to the lack of an accurate measurement tool.
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- The study aimed to assess the rates of depression, anxiety, and PTSD among women years after experiencing hyperemesis gravidarum (HG) and how these mental health issues relate to the severity of HG symptoms.
- A cohort of 215 women who had been hospitalized for HG provided data through questionnaires measuring anxiety, depression, and PTSD both six weeks and approximately 4.5 years postpartum.
- Results indicated that a significant number of participants experienced elevated levels of anxiety (39.7%) and depression (27.4%) during follow-up, alongside a notable prevalence of PTSD (21.9%), with increased HG severity linked to higher mental health risk scores.
Levothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
Lancet Diabetes Endocrinol
May 2022
Background: Women positive for thyroid peroxidase antibodies (TPO-Ab) have a higher risk of recurrent pregnancy loss. Evidence on whether levothyroxine treatment improves pregnancy outcomes in women who are TPO-Ab positive women with recurrent pregnancy loss is scarce. The aim of this study was to determine if levothyroxine increases live birth rates in women who were TPO-Ab positive with recurrent pregnancy loss and normal thyroid function.
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- The study explored how the severity of hyperemesis gravidarum (HG) in pregnant women affected cardiometabolic markers in their babies' cord blood.
- It found that lower maternal weight gain was linked to higher levels of glucose and Apo-B in the cord blood, but other measures of HG severity and the use of enteral tube feeding did not show significant associations.
- Overall, while lower weight gain was a notable factor, the study concluded that other HG severity factors and enteral tube feeding did not impact the cardiometabolic markers in the offspring.
Evaluation of low-dose aspirin in the prevention of recurrent spontaneous preterm labour (the APRIL study): A multicentre, randomised, double-blinded, placebo-controlled trial.
PLoS Med
February 2022
Background: Preterm birth is the leading cause of neonatal morbidity and mortality. The recurrence rate of spontaneous preterm birth is high, and additional preventive measures are required. Our objective was to assess the effectiveness of low-dose aspirin compared to placebo in the prevention of preterm birth in women with a previous spontaneous preterm birth.
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