Publications by authors named "D N Nikitina"

Objective: To study the efficacy and safety of balloon dilation as the first choice method in the treatment of children of the first year of life with acquired subglottic stenosis.

Material And Methods: A retrospective analysis of the treatment of 25 patients aged 27 days to 11 months of life (average age 5.3±3.

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Article Synopsis
  • Intratumoral bacteria, specifically Colibactin-producing (CoPEC) strains, are linked to tumor heterogeneity and cancer recurrence by creating a low-immunity environment in right-sided colorectal tumors.
  • These bacteria foster lipid accumulation in cancer cells, which helps them survive and resist chemotherapy, correlating with worse survival rates in advanced-stage colorectal cancer patients.
  • Targeting the metabolic changes induced by CoPEC with specific inhibitors has shown potential in restoring chemotherapy sensitivity, suggesting a new approach to improve treatment outcomes for patients colonized by these bacteria.
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Recent studies highlight the presence of bacterial sequences in the human blood, suggesting potential clinical significance for circulating microbial signatures. These sequences could presumably serve in the diagnosis, prediction, or monitoring of various health conditions. Ensuring the similarity of samples before bacterial analysis is crucial, especially when combining samples from different biobanks prepared under varying conditions (such as different DNA extraction kits, centrifugation conditions, blood collection tubes, etc.

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Next-generation sequencing technologies have started a new era of respiratory tract research in recent years. Alterations in the respiratory microbiome between healthy and malignant conditions have been revealed. However, the composition of the microbiome varies among studies, even in similar medical conditions.

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Helicobacter pylori (H. pylori) infection has been considered as the main causal factor in gastric carcinogenesis, but other bacterial species may also play an important role in pathophysiology of gastric cancer. The aim of the study was to explore the link between gastric cancer prognosis and the mucosal microbial community in tumorous and adjacent gastric tissue.

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