Publications by authors named "D N Mbanya"
Predictive Efficacy of Dual Therapies Combining Integrase Strand Transfer Inhibitors with Second-Generation Non-Nucleoside Reverse Transcriptase Inhibitors Following HIV-1 Treatment Failure in Cameroon: Implications for the Use of a Long-Acting Therapeutic Strategy in Low- and Middle-Income Countries.
Viruses
November 2024
Dual therapies (DT) combining integrase strand transfer inhibitors (INSTIs) with second-generation non-nucleoside reverse transcriptase inhibitors (2nd-Gen-NNRTIs) offer new possibilities for HIV treatment to improve adherence. However, drug resistance associated mutations (RAMs) to prior antiretrovirals may jeopardize the efficacy of DT. We herein describe the predicted efficacy of DT combining INSTIs + 2nd-Gen-NNRTI following treatment failure among Cameroonian patients.
View Article and Find Full Text PDFRates of Viral Non-Suppression and Acquired HIV-1 Drug Resistance Emergence among Children during the Sociopolitical Crisis in the Northwest Region of Cameroon: A Call for Improved Monitoring Strategies.
Curr HIV Res
November 2024
Background: Virological failure (VF) among children remains concerning, with high risks of HIV drug resistance (HIVDR) emergence and increased disease progression. Therefore, monitoring of viral non-suppression and emerging HIVDR is crucial, especially in the frame of sociopolitical unrest.
Objective: The study sought to determine the prevalence of VF and evaluate the acquired HIVDR and viral genetic diversity among children in the Northwest region of Cameroon during the ongoing sociopolitical crisis.
Article Synopsis
- In Cameroon, it's hard to find and understand bleeding problems, especially minor ones like epistaxis (nosebleeds) and menorrhagia (heavy periods).
- A study looked at 60 patients to see what's happening with their blood and why they bleed.
- The results showed that many patients had issues with their blood that could cause bleeding, with the most common problems being low levels of a special protein and longer bleeding times.
Background: HDV antibody testing is recommended for universal screening and as the first line in an HDV double reflex testing strategy for effectively identifying patients with active infection for therapeutic treatments.
Objective: The aim of this study is to evaluate the performance of a newly developed ARCHITECT HDV Total Ig (ARCHITECT HDV Ig) prototype assay.
Study Design: Performance characteristics were determined for the ARCHITECT HDV Ig and a reference test, LIAISON XL Anti-HDV using a well-characterized specimen panel, comprising HDV RNA positive (n = 62) and negative (n = 70) samples, and healthy US blood donors.
Article Synopsis
- The project reviewed the global use of nucleic acid amplification testing (NAT) in blood services to detect viral and parasite nucleic acids and reduce transfusion-related infections.
- A survey conducted among members of the International Society of Blood Transfusion revealed a significant increase in NAT adoption over the past decade, with data showing low but notable positivity rates for various viruses in blood donations.
- While NAT has enhanced blood transfusion safety worldwide, there is a call to address economic barriers that prevent some regions from implementing these important testing methods.