Publications by authors named "D N Khochanskiy"
Background: Frailty has been proven to be associated with mortality after orthotopic heart transplantation (OHT). The aim of our study was to determine the impact of frailty on mortality in the current era using pretransplant mechanical cardiac support (MCS).
Methods: We retrospectively calculated the frailty scores of 471 patients undergoing OHT in a single institution between January 2012 and August 2022.
Article Synopsis
- The study investigates the impact of thyroid hormone levels on outcomes in patients undergoing heart transplantation (HTx).
- During a period from 2013 to 2020, serum levels of thyroid hormones were measured pre- and post-HTx in 283 patients, revealing significant decreases in TSH, fT3, and fT4 after surgery.
- Administration of levothyroxine to both donors and recipients was linked to improved survival rates at various time points post-transplantation.
- The research also explored the relationship between thyroid hormone action in the heart and the use of mechanical circulatory support, with specific gene expressions linked to the need for such support, although no significant differences were found in certain gene expressions between different groups.
There are individual differences in the tolerance to hypoxia and stress. Stress can contribute to the development of various diseases, including inflammatory bowel disease. It was found that inflammatory bowel diseases in animals susceptible to hypoxia runs more severe course than in tolerant animals.
View Article and Find Full Text PDFIt is a common fact, that the content of sex hormones in humans and animals varies in different age periods. The functional state of the immune system also changes with age. However, sex differences studies of inflammatory and immune responses during puberty prevail in literature.
View Article and Find Full Text PDFMorphological, morphometric, and ultrastructural analysis of the nerve fibers in the colon mucosa was performed in C57BL/6 mice at various terms of development of acute colitis induced by dextran sodium sulphate. The nerve fibers were labeled with antibodies to pan-neuronal marker βIII-tubulin. The progression of inflammatory and ulcerative processes in the mucosa on days 3-5 was associated with hyperplasia and hypertrophy of nerve fibers that peaked on day 7 after colitis induction.
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