Publications by authors named "D N Dhanasekaran"
High-pressure processing (HPP) is used as a non-thermal approach for controlling microbial viability. The purposes of this study were to (i) establish the decimal reduction times (D-values) for pathogenic bacteria during 350 MPa HPP treatment,; (ii) evaluate the impact of 350 MPa HPP on total plate count (TPC), yeasts and molds (YM), and lactic acid bacteria (LAB) in camel milk; (iii) investigate the behavior of several spoilage-causing bacteria during storage at 4 °C and 10 °C for up to 10 d post-HPP treatment; and (iv) assess the effect of HPP on the protein degradation of camel milk. The D-values for , O157:H7, and spp.
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- Understanding lncRNA-miRNA interactions is important for cellular signaling and cancer studies, particularly in how the long non-coding RNA (lncRNA) UCA1 impacts ovarian cancer through its relationship with let-7 miRNAs.* -
- The research posits that UCA1 functions as a competing endogenous RNA (ceRNA), sequestering let-7 miRNAs to influence the expression of their target genes, which can lead to increased cancer progression.* -
- A new technique called Modified Crosslinking and Immunoprecipitation (M-CLIP) was developed to effectively capture these interactions, confirming that UCA1 binds with let-7 miRNAs and could potentially reveal new insights into cancer progression mechanisms
Several soluble factors secreted by the stromal cells and cancer cells within the tumor microenvironment facilitate the progression and invasiveness of ovarian cancer. In ovarian cancer cells, lysophosphatidic acid (LPA) modulates the transcriptome profile and promotes cell invasiveness by the downregulation of autophagy. Here, we further elucidate this mechanism by focusing on the molecular and cellular events regulating autophagy.
View Article and Find Full Text PDFPsychedelic mushrooms belonging to basidiomycota have gained prominence in research due to the range of hallucinogenic compounds. To combat the challenge of antimicrobial resistance, exploring alternative antimicrobial peptides has become crucial. In this study, we present the proteomic analysis of psychedelic mushroom.
View Article and Find Full Text PDFCancer represents one of the diseases with the highest mortality rate worldwide. The burden of cancer continues to increase, not only affecting the health-related quality of life of patients but also causing an elevated global financial impact. The complexity and heterogeneity of cancer pose significant challenges in research and clinical practice, contributing to increase the failure rate of clinical trials for antitumoral drugs.
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