Publications by authors named "D Mutimer"
Hepatitis B elimination objectives can only be realised if new patient linkage to care is matched by long-term patient retention in care. We previously showed in adult chronic hepatitis B (CHB) patients that retention in care was inferior in younger patients and in patients from non-Asian ethnicities. The present study explores further the rates and determinants of loss to follow-up in a cohort of 271 young patients (aged 16-21 years at baseline).
View Article and Find Full Text PDFHepatitis B e antigen (HBeAg) loss is a key event in the natural history of chronic hepatitis B virus infection. The rate and determinants of HBeAg loss depend upon cohort characteristics at baseline. Few studies have examined the age-dependent rate, and none have examined the effect of patient sex and ethnicity on the age-dependant rate.
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- The study aimed to assess mortality rates in patients treated for hepatitis C using modern interferon-free, direct-acting antivirals and compare them to the general populace.
- A total of 21,790 patients treated between 2014 and 2019 were analyzed, categorized by liver disease severity, with follow-up ending either at death or by the end of 2019.
- Results showed a 7% mortality rate during follow-up, with deaths primarily from drug-related issues, liver failure, and liver cancer, and overall mortality rates significantly exceeded those of the general population, especially for patients with more advanced liver disease.
Most clinic attenders with chronic hepatitis B (CHB) are serum HBeAg-negative, and a minority will require suppressive antiviral treatment. Expert guidelines propose schedules for the monitoring of untreated patients, but the recommended frequency of patient review does not reflect recognised demographic determinants of HBeAg-negative chronic hepatitis. Also, the impact of patient ethnicity on risk has not been defined.
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