Osteomyelitis and Septic Arthritis in the Darwin Prospective Melioidosis Study.

Background: Melioidosis is a multisystem infectious disease caused by the environmental bacterium . Osteomyelitis (OM) and septic arthritis (SA) are uncommon primary presentations for melioidosis but important secondary foci, often requiring prolonged therapy and multiple surgeries. We characterized the epidemiology, presentation, treatment, and outcomes of patients from 24 years of the Darwin Prospective Melioidosis Study (DPMS).

Interruption of the visual cycle in a novel animal model induces progressive vision loss resembling Stargardts Disease.

Mutations in the gene ABCA4 coding for photoreceptor-specific ATP-binding cassette subfamily A member 4, are responsible for Stargardts Disease type 1 (STGD1), the most common form of inherited macular degeneration. STGD1 typically declares early in life and leads to severe visual handicap. Abca4 gene-deletion mouse models of STGD1 accumulate lipofuscin, a hallmark of the disease, but unlike the human disease show no or only moderate structural changes and no functional decline.

Equipping a Wyatt multiangle, multidetector instrument for real-time particle and polymer sizing by simultaneous multiple-angle dynamic and static light scattering.

Well-constructed instruments may continue to perform beyond their manufacturer-supported service lifetime, which is typically limited by computer operating system compatibility or the availability of spare parts. Often, such equipment is condemned to surplus and destroyed. End-of-life plans that retain some of the material and energy used to create scientific instruments are of interest, just as in other manufacturing sectors.

ERBB2/HOXB13 co-amplification with interstitial loss of BRCA1 defines a unique subset of breast cancers.

Background: The HOXB13/IL17RB gene expression biomarker has been shown to predict response to adjuvant and extended endocrine therapy in patients with early-stage ER+ HER2- breast tumors. HOXB13 gene expression is the primary determinant driving the prognostic and endocrine treatment-predictive performance of the biomarker. Currently, there is limited data on HOXB13 expression in HER2+ and ER- breast cancers.

Promoting psychological safety in simulation using a novel visual tool: A mixed-methods quasi-experimental study.

Background: Psychological safety is imperative for effective simulation-based learning within healthcare education, yet it is challenging for educators to establish. A visual tool, "Simulation Tool to Enhance Psychological Safety" (STEPS) was incorporated into simulation-based activities for prelicensure nursing students to support (or strengthen) psychological safety.

Objective: The purpose of this study was to determine the impact of the STEPS tool on psychological safety during simulated learning for prelicensure nursing students.