WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks.

Werner syndrome (WS) is a human genetic disorder characterized by extensive clinical features of premature aging. Ataxia-telengiectasia (A-T) is a multisystem human genomic instability syndrome that includes premature aging in some of the patients. WRN and ATM, the proteins defective in WS and A-T, respectively, play significant roles in the maintenance of genomic stability and are involved in several DNA metabolic pathways.

Orthostatic hypotensive effect of antipsychotic drugs in Wistar rats by in vivo and in vitro studies of alpha1-adrenoceptor function.

Rationale: Many antipsychotics cause orthostatic hypotension possibly due to antagonist action on resistance vessel alpha1A-adrenoceptors (alpha1A-AR).

Objective: We have tested this possibility by determining in Wistar rats how the orthostatic hypotensive effect of several antipsychotic drugs compares with their affinity for adrenoceptors in mesenteric small arteries (MSA with mainly alpha1A-AR) and aorta (mainly alpha1D-AR).

Materials And Methods: Using a tilt setup, orthostatic hypotension was measured in anaesthetized rats for prazosin and the antipsychotics haloperidol, sertindole, risperidone, clozapine, ziprasidone, domperidone, olanzapine, and aripiprazole.

[Maintaining cleanliness and protecting health as proclaimed by Koran texts and hadiths of Mohammed S.A.V.S].

Beside its basic Message (modesty and faith to the Only One God) islam is a style of life and a way of consideration to everything in our environment: nature, people, animals, things, family, neighbours etc. Islam has a specific attitude concerning science and education, health, nutrition, work, defense of country, including the most refined dimensions of practical life. Islam considers specially hygiene and health in general (from the proclaimed tenets on personal hygiene keeping protection of our environment).