Publications by authors named "D Muduly"
The rippled pattern of basal cell carcinoma (BCC) is a very uncommon variant and poses a diagnostic challenge. A 52-year-old male presented with an ulcerated lesion over the scalp for 8 years. The wedge biopsy of the lesion showed an infiltrating tumour in the upper dermis and mid-dermis with focal attachment with the epidermis.
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- Differentiating liver tumors is crucial for appropriate treatment and prognosis, but non-invasive methods often struggle due to overlapping features in imaging.
- This study evaluated CT perfusion parameters in 48 patients to help distinguish hepatocellular carcinoma (HCC) from other liver tumors, using statistical analysis to identify significant perfusion metrics.
- Results indicated that blood volume (BV) was particularly effective in differentiating HCC from other tumors, achieving a sensitivity of 96.6% and specificity of 80% at a threshold of 8.3 ml/100 ml/min, alongside several other significant perfusion parameters.
Aim To evaluate the role of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) in characterizing suspicious lesions in dense breasts compared to ultrasonography (USG). Materials and methods Eighty-two consecutive female patients with suspicious lesions in dense breast parenchyma showing the American College of Radiology Breast Imaging Reporting And Data System (ACR BI-RADS) c/d composition on mammography underwent USG, where 63 lesions of 63 patients were suspicious. They underwent multiparametric MRI, followed by histopathological evaluation (HPE) of the lesions.
View Article and Find Full Text PDFEssential cancer protein identification using graph-based random walk with restart.
Comput Methods Biomech Biomed Engin
September 2024
Protein-protein interaction (PPI) network analysis holds significant promise for cancer diagnosis and drug target identification. This paper introduces a novel random walk-based method called essential cancer protein identification using graph-based random walk with restart (EPI-GBRWR) to address this gap. This proposed method incorporates local and global topological features of proteins, enhancing the accuracy of essential protein identification in PPI networks.
View Article and Find Full Text PDFObjectives: The presence of lymphovascular invasion (LVI), perineural invasion (PNI) and extranodal extension (ENE) have shown adverse outcomes in oral squamous cell carcinoma (OSCC). This study evaluated the impact of LVI, PNI and ENE, individually and in combination, on survival outcomes in OSCC.
Material And Methods: A retrospective analysis of a prospectively maintained oral cancer database was done from January 2017 to March 2023.