Publications by authors named "D Morissette"

Article Synopsis
  • The interaction between the phosphoprotein P and nucleoprotein N of the Respiratory Syncytial Virus (RSV) is crucial for forming the holo RSV polymerase needed for viral replication.
  • In testing antiviral drugs that target the N-P interaction, researchers found that the binding dynamics are influenced by the length and flexibility of C-terminal P peptides and their phosphorylation status.
  • The study resulted in identifying key features for an effective RSV N-P inhibition assay, validated with the M76 molecule, a compound with antiviral properties, paving the way for further drug screening.
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Background: Thoracic trauma represents 5% of all battlefield injuries. Communicating pneumothoraces resulting in tension physiology remain an important etiology of prehospital mortality. In addressing penetrating chest trauma, current Tactical Combat Casualty Care (TCCC) guidelines advocate the immediate placement of a vented chest seal device.

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Based on careful review of the Tactical Combat Casualty Care (TCCC) Guidelines, the authors developed a list of proposed changes for inclusion in a comprehensive change proposal. To be included in the proposal, individual changes had to meet at least one of three criteria: (1) The change was primarily tactical rather than clinical; (2) the change was a minor modification to the language of an existing TCCC Guideline; and (3) the change, though clinical, was straightforward and noncontentious. The authors presented their list to the TCCC Working Group for review and approval at the 7 September 2016 meeting of the Committee on Tactical Combat Casualty Care (CoTCCC).

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Mycoparasitism by antagonistic fungi involves changes in the biochemistry and physiology of both partners. Analysis of genes that are expressed during mycoparasite-host interaction represents a powerful strategy to obtain insight into the molecular events underlying these changes. The aim of this study is to identify genes whose expression is upregulated when the mycoparasite Stachybotrys elegans is in direct confrontation with its host Rhizoctonia solani.

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