Publications by authors named "D Monroe"
Motivated by studies showing an association between beta blocker (BB) use and positive bone outcomes, a pilot randomized control trial (RCT) was performed at the Mayo Clinic which randomized postmenopausal women to placebo, propranolol (40 or 80 mg twice daily), atenolol (50 mg/day), or nebivolol (5 mg/day) to determine changes in bone turnover markers (BTMs) and in bone mineral density (BMD) over 20 weeks. Pharmacogenetic effects and microRNA-mediated mechanisms involving beta adrenergic receptor and related genes have previously been found. We sought to validate these effects and discover new candidates in an ancillary study to the pilot clinical trial.
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- An obstetric fistula is a severe complication from childbirth that creates an abnormal connection between the urinary tract or gastrointestinal tract and the genital tract, often due to prolonged and obstructed labor.
- Contributing factors like early marriage, poverty, and lack of access to proper healthcare have led to a high incidence of this condition in Ethiopia.
- Australian doctors Reginald and Catherine Hamlin moved to Ethiopia in 1959, developed a surgical technique for fistula repair, and founded the Addis Ababa Fistula Repair Hospital, helping over 60,000 women with transformative surgeries.
Blood coagulation is a vital physiological process involving a complex network of biochemical reactions, which converge to form a blood clot that repairs vascular injury. This process unfolds in three phases: initiation, amplification, and propagation, ultimately leading to thrombin formation. Coagulation begins when tissue factor (TF) is exposed on an injured vessel's wall.
View Article and Find Full Text PDFBackground: In healthy individuals, plasma levels of clotting proteins naturally vary within a range of 50% to 150% of their mean values. We do not know how these variations modify thrombin generation.
Objectives: To assess the impact of protein level variations on simulated thrombin generation in normal and factor (F)VIII-, FIX-, or FXI-deficient blood.