Publications by authors named "D Mogica-Martinez"
Article Synopsis
- * The study, involving 13 hospitals, found that the majority of patients (88%) were male, all experienced bacterial infections, and 30% had fungal infections; complications related to the BCG vaccine occurred in 58% of vaccinated patients.
- * Genetic analysis revealed X-linked CGD was most common, with 89% diagnosed biologically and 89% genetically; notable findings include a significant presence of CYBA and NCF2 mutations,
Background: Common variable immunodeficiency (CVID) is a heterogeneous group of primary antibody deficiencies defined by marked reductions in serum IgG, IgA and/or IgM levels and recurrent bacterial infections. Some patients are associated with defects in T cells and regulatory T cells (Tregs), resulting in recurrent viral infections and early-onset autoimmune disease.
Methods: We analyzed whether there is an association between Tregs cells (CD4+CD25+CD127 and CD4+CD25+FoxP3+); memory T cells (CD4+CD45RO+); memory B cells (CD19+CD27-IgD-); and CD21 B cells (CD19+CD38CD21); as well as autoimmune manifestations in 36 patients with CVID (25 women and 11 men, mean age 24 years), all by flow cytometry.
X-linked agammaglobulinemia (XLA) is caused by BTK mutations, patients typically show <2% of peripheral B cells and reduced levels of all immunoglobulins; they suffer from recurrent infections of bacterial origin; however, viral infections, autoimmune-like diseases, and an increased risk of developing gastric cancer are also reported. In this work, we report the BTK mutations and clinical features of 12 patients diagnosed with XLA. Furthermore, a clinical revision is also presented for an additional cohort of previously reported patients with XLA.
View Article and Find Full Text PDFLymphocytes and B-cell abnormalities in patients with common variable immunodeficiency (CVID).
Allergol Immunopathol (Madr)
October 2014
Background And Aims: Common variable immunodeficiency (CVID) is a primary antibody deficiency characterised by decreased antibody production and low or normal B-cell numbers. To elucidate the clinical and immunological heterogeneity of CVID, we studied 16 patients diagnosed with CVID.
Methods: We analysed B, T and NK cell populations.
Purpose: To evaluate the lipopolysaccharide (LPS)-induced pro-inflammatory cytokine response by peripheral blood mononuclear cells (PBMCs) from XLA patients.
Methods: Thirteen patients with XLA were included in the study. LPS-induced TNF-α, IL-1β, IL-6, and IL-10 production was determined in PBMCs from patients and matched healthy controls by ELISA.