Effect of butyric short-chain fatty acids on the bioelectric and contractile activity of gastrointestinal smooth muscle tissues.

The present study was undertaken to investigate the effect of butyric (C4) short-chain fatty acids on the bioelectric and contractile activity of smooth muscle (SM) tissues from rat and guinea-pig gastrointestinal tracts. The study was conducted in vitro on isolated SM preparations of rat gastric corpus and guinea pig taenia coli. The following methods were used: 1.

Effect of a balanced amino acid-based diet on the nitrogen metabolism in carbon tetrachloride-induced liver injury.

In experimental study, in white rats with carbon tetrachloride-induced injury of the liver, branched-chain amino acids of vegetable origin were found to display hepatoprotective activity against the CCL4 toxic effect. They reduced the ammonia and glutamine concentrations in the blood and brains of the experimental animals and caused a significant decrease in the concentration of the aromatic amino acids (phenylalanine and tyrosine) in the animals' brains. The results of the study indicate that branched-chain amino acids are related to the pathogenesis of hepatic encephalopathy.

Short chain fatty acid-induced hyperventilation is due to PGF2-alpha.

While studying the significance of the short chain fatty acids (SCFAs) in the pathogenesis of hyperventilation, we have found that experimental rabbits injected with SCFA sodium salt (4 mmol/kg b.wt) develop hyperventilation 20 min later. This hyperventilation results in a decrease of PCO2 in the arterial blood from 32.

The role of the octanoic fatty acid in the pathogenesis of the metabolic alkalosis in experimental liver failure.

Octanoate was found to stimulate the muscle proteins catabolism in rats with portacaval anastomosis thus increasing the amounts of 3-methylhistidine, creatinine, ammonium and urea in the excreted urine. The intensive decomposition of the endogenous proteins also produced great amounts of HCO3- whose levels increased in both the urine and blood. It is suggested that in hepatic insufficiency octanoate causes metabolic acidosis through: a) more intensive catabolism of the muscle proteins whose decomposition results in greater amounts of HCO3-, b) metabolization of octanoate to HCO3-, and c) inhibition of the ornithine cycle.

Effects of the medium chain octanoic fatty acid on the contractile activity of vascular smooth muscle tissues.

Multiple elevation of the octanoic fatty acid level in human sera is often observed in some hepatic diseases which are accompanied by cardiovascular disorders, hypotension, and increased cardiac stroke volume. Different experiments reveal the hypotensive effect of octanoate. The present study investigates the octanoate action on the bioelectric and contractile activity of vascular smooth muscle tissues.