Publications by authors named "D Miley"
Objectives: To investigate the correlation between gingival thickness (GT) and buccal bone thickness (BBT), as well as the effects of GT, BBT, bone crest level (BC), and tooth position on the buccal gingival margin location of maxillary teeth in the esthetic zone.
Materials And Methods: Periodontally healthy subjects with prior cone beam computed tomography and intraoral scans for dental implant planning were included. The hard and soft tissue measurements were retrospectively analyzed digitally.
Purpose: A lack of representative human disease models has limited the translation of new and more effective treatments in uveal melanoma (UM), the most common primary adult intraocular malignancy. To fill this critical need, we developed and characterized a multicenter biobank of UM patient-derived organoids (PDOs).
Methods: UM patients requiring enucleation from 2019 to 2024 donated tumor tissue for PDO generation.
Article Synopsis
- The study aimed to noninvasively measure supracrestal tissue attachment dimensions (STADs) and explore their relationships with other dental factors like gingival thickness and tooth position.
- Researchers involved 19 healthy subjects and utilized advanced imaging techniques and statistical analyses to assess 203 teeth, finding variations in STADs based on tooth location and associated factors.
- Results indicated that STADs were generally larger in mandibular teeth and showed complex correlations with gingival and bone characteristics, emphasizing the importance of tooth position in understanding STAD dynamics.
To investigate downstream molecular changes caused by mitogen-activated protein kinase (MEK) inhibitor treatment and further explore the impact of direct knockdown of early growth response-1 ( EGR1 ) in melanoma cell culture. RNA-sequencing (RNA-Seq) was performed to determine gene expression changes with MEK inhibitor treatment. Treatment with MEK inhibitor (trametinib) was then assessed in two cutaneous (MEL888, MEL624) and one conjunctival (YUARGE 13-3064) melanoma cell line.
View Article and Find Full Text PDFPurpose/objectives: The objective of this study was to evaluate the effectiveness of an Electronic-Periodontal-Diagnosis-Tool (EPDT) to facilitate the formulation of a correct periodontal diagnosis and analyze students' perceptions of the use of the EPDT.
Methods: Fifty Year-3 students who recently started their clinical training, were randomly assigned to two groups. Two clinical scenarios involving challenging periodontal diagnoses, each one with unique components, variables, and categories were distributed with specific instructions.