Publications by authors named "D Mileto"
Arboviral diseases are a growing global health concern. Pre-existing autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) can underlie encephalitis due to West Nile virus (WNV) (∼40% of patients) and tick-borne encephalitis (TBE, due to TBE virus [TBEV]) (∼10%). We report here that these auto-Abs can also underlie severe forms of rarer arboviral infections.
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- Arthropod-borne viruses like dengue virus (DENV) are a major global health issue, infecting around 400 million people annually and causing outbreaks even in non-endemic regions.
- The study aimed to improve serological diagnosis and identify new drugs by mapping immunogenic protein regions of DENV through high-density peptide arrays and computational methods.
- Twenty-four specific peptides were found that could distinguish DENV from other flaviviruses, with two peptides potentially serving as a serum biomarker for DENV infection, which may aid in developing diagnostic and preventative strategies.
Background: Severe and prolonged mpox courses have been described during the 2022-2023 outbreak. Identifying predictors of severe evolution is crucial for improving management and therapeutic strategies. We explored the predictors of mpox severity and tested the association between mpox severity and viral load in biological fluids.
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