Publications by authors named "D Messerer"
Article Synopsis
- Traumatic brain injury (TBI) is a leading cause of death, complicating the development of effective therapies due to the unique nature of each injury.
- Clinical questions regarding the benefits of measuring intracranial pressure, cerebral perfusion pressure, and surgical interventions remain largely unanswered.
- This study focused on acute subdural hematoma in a porcine model to better understand secondary brain injury and the effects of different injury patterns on outcomes, highlighting the need for comprehensive models to improve TBI treatment translation.
Artificial intelligence is rapidly transforming the field of health science and medical education, but less is known about the students´ competencies related to knowledge, skills and attitudes towards the application of AI tools like ChatGPT. Therefore, a unicentric questionnaire-based cross-sectional study was applied to students in the medical field ( = 207). The data revealed that while most students were familiar with ChatGPT (66.
View Article and Find Full Text PDFBackground: C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune cell activation via unknown molecular mechanisms.
Results: In a multi-translational study of systemic inflammation, we found a time- and inflammation-dependent pCRP dissociation into mCRP.
In a patient with permanent neonatal syndromic diabetes clinically similar to cases with ONECUT1 biallelic mutations, we identified a disease-causing deletion located upstream of ONECUT1. Through genetic, genomic, and functional studies, we identified a crucial regulatory region acting as an enhancer of ONECUT1 specifically during pancreatic development. This enhancer region contains a low-frequency variant showing a strong association with type 2 diabetes and other glycemic traits, thus extending the contribution of this region to common forms of diabetes.
View Article and Find Full Text PDFArticle Synopsis
- Research shows that despite current prevention methods, early recurrent strokes are still common, especially in patients with atherosclerosis, with over 10% experiencing repeat events.
- A new mouse model revealed that strokes activate the AIM2 inflammasome in atherosclerotic plaques due to increased circulating cell-free DNA, leading to inflammation, plaque destabilization, and recurrent strokes.
- Targeting the mechanisms of DNA-mediated inflammasome activation may offer new treatment options to reduce the high rate of recurrent strokes in at-risk patients.