Publications by authors named "D Menz"
Purpose: The complications with cytotoxic perfluorooctane (PFO) batches reported in 2015 were attributed to reactive underfluorinated impurities whose chemical identity and behavior still need to be clarified.
Material And Methods: We analyzed original packaged samples of Alaocta batches involved in several reported cases of retinal toxicity. (A) The impurity profile was determined.
How to Ward Off Retinal Toxicity of Perfluorooctane and Other Perfluorocarbon Liquids?
Invest Ophthalmol Vis Sci
October 2018
Purpose: Reactive and underfluorinated impurities are acknowledged as a source of cytotoxicity of perfluorocarbon liquids (PFCLs) used as blood substitutes. To determine whether this is also a relevant factor in retinal toxicity, we analyzed eight PFO batches associated with adverse ocular events.
Methods: (A) The amount of reactive and underflurinated impurities was analyzed by fluoride-selective potentiometry and expressed as H-value.
Background: Perfluorocarbon liquids (PFCL) cause retinal damage when used as long-term ocular endotamponades. Whether these changes are related to the mechanical or to the chemical properties of PFCL is unclear. The purpose of this study was to evaluate pressure spikes or shearing forces during endotamponade with PFCL and standardised eye movements.
View Article and Find Full Text PDFAn epidemic of sticky silicone oil at the Rotterdam Eye Hospital. Patient review and chemical analyses.
Graefes Arch Clin Exp Ophthalmol
June 2008
Purpose: To report and study the phenomenon of abnormal silicone oil adherent to the retina at the time of removal in a number of patients.
Materials And Methods: Chart review was performed to identify possible patient or procedural factors that could predispose to sticky silicone oil formation. Gas chromatography-mass spectroscopy and nuclear magnetic resonance spectroscopy analyses were performed on sticky silicone oil samples, on perfluorocarbon liquid and on silicone oil samples straight from the vial.