Publications by authors named "D Mclean"

Background: Operations Management meetings in NHS hospitals provide an opportunity for operational and clinical staff to monitor demand and capacity and manage patient flow. These meetings play an important role in the achievement of resilient performance over time. However, little is known about the work that takes place within these meetings in the United Kingdom's National Health Service.

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Background: Amidst the difficulty and contentiousness of improving hospitals, a relatively new approach is the Relational Model of Organizational Change (RMOC). However, this approach has its own challenges, including reports that its focus on communication and relationships is undervalued despite evidence supporting its use to facilitate practice improvements in hospitals. Research suggests power dynamics in hospitals influences how the RMOC is used, but the precise mechanisms through which this occurs have not been fully examined.

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Deciphering the connectome, the ensemble of synaptic connections that underlie brain function, is a central goal of neuroscience research. Here we report the in vivo mapping of connections between presynaptic and postsynaptic partners in zebrafish, by adapting the trans-Tango genetic approach that was first developed for anterograde transsynaptic tracing in Drosophila. Neural connections were visualized between synaptic partners in larval retina, brain and spinal cord and followed over development.

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Article Synopsis
  • The study aimed to improve the efficiency of measuring neurotransmitter metabolites (5-HIAA, VMA, and HVA) in urine, which are crucial for diagnosing neuroendocrine tumors, through automation.
  • The method involved using automated supported liquid extraction (SLE) combined with liquid chromatography tandem mass spectrometry (LC-MS/MS) for accurate measurement and analysis of these metabolites.
  • Results showed high recovery rates and successful validation across various performance criteria, with automation leading to significant time savings in the process.
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