Publications by authors named "D McHugh"
Senescence as a therapeutic target in cancer and age-related diseases.
Nat Rev Drug Discov
January 2025
Cellular senescence is a stress response that restrains the growth of aged, damaged or abnormal cells. Thus, senescence has a crucial role in development, tissue maintenance and cancer prevention. However, lingering senescent cells fuel chronic inflammation through the acquisition of a senescence-associated secretory phenotype (SASP), which contributes to cancer and age-related tissue dysfunction.
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- Hypoxia contributes to treatment resistance in solid tumors, and this study investigated whether oxygen-enhanced MRI (OE-MRI) can reliably measure changes in hypoxic volume in patients with HPV-related oropharyngeal cancer during radiotherapy.
- 27 patients underwent imaging before and during treatment, showing that hypoxic volume decreased significantly at two and four weeks into therapy, with notable variations in treatment response across different lesions.
- Results indicate that significant modifications in tumor hypoxia can occur early in treatment, with half of the patients experiencing differing hypoxic changes in primary versus nodal tumors, which could influence patient management and treatment strategies.
Purpose: Paclitaxel, ifosfamide, and cisplatin (TIP) is an established salvage regimen for germ cell tumors (GCT) on the basis of a phase II trial, but efficacy on a large patient cohort including patients with unfavorable risk features and long-term outcomes has not been reported. Herein, we report updated treatment efficacy and long-term follow-up with TIP.
Patients And Methods: Patients with GCT who received TIP after cisplatin-based chemotherapy were eligible.