Effects of forage feeding level on ruminal pH and metabolic adaptation of the rumen epithelium in pre-weaned Jersey calves.

The objective of this study was to determine the effect of limiting forage provision in pre-weaned calves on ruminal pH and short chain fatty acid (SCFA) transport capacity during the pre-weaning period. Twelve Jersey bull calves (age = 1.9 ± 0.

Overview of Systemic Autoinflammatory Diseases.

Systemic autoinflammatory diseases (SAID) are a growing family of disorders of the innate immune system. Over the years, there have been changes in the definition, classification and nomenclature of SAID as new syndromes and pathophysiologic mechanisms continue to be described. Recognizing the clinical manifestations of SAID is important for their early diagnosis and management.

The Antiphospholipid Syndrome in the Pediatric Population.

Pediatric antiphospholipid syndrome (APS) is characterized by autoantibodies directed against protein complexes on cellular membranes and leads to a prothrombotic, proinflammatory state. A child with APS may present with venous, arterial, or small vessel thrombosis. Other manifestations of APS include nonthrombotic manifestations, such as hematologic and neurologic symptoms.

Loss-of-function variants in cause X-linked childhood-onset systemic lupus erythematosus.

Objectives: Families that contain multiple siblings affected with childhood onset of systemic lupus erythematosus (SLE) likely have strong genetic predispositions. We performed whole exome sequencing (WES) to identify familial rare risk variants and to assess their effects in lupus.

Methods: Sanger sequencing validated the two ultra-rare, predicted pathogenic risk variants discovered by WES and identified additional variants in 562 additional patients with SLE.