Publications by authors named "D Mazzatenta"

Background: Endoscopic transorbital approach (eTOA) has been recently proposed as an alternative skull base approach. However, its feasibility for deeper lesions can be hampered by a reduced surgical maneuverability. Aim of this study is to consider how its extension through orbital rim resection can overcome this limitation, and to compare two different techniques for its removal.

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Introduction: Endoscopic endonasal approach (EEA) plays a central role in the treatment of GH-secreting pituitary adenomas (PAs)/pituitary neuroendocrine tumors (PitNETs), allowing to treat not only micro- or regular macro- PAs/PitNEts, but also more complex cases, otherwise requiring a transcranial or other open approaches.

Materials And Methods: All consecutive cases of GH-secreting PAs/PitNETs treated by EEA from May 1998 to June 2023 at our Institution were included. Patients clinical, bio-chemical, and neuroradiological features were considered, as well the surgical approach adopted for each case and its related complications.

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Article Synopsis
  • - Acromegaly is a rare condition caused by excessive growth hormone secretion, typically from a pituitary adenoma, leading to high levels of insulin-like growth factor 1 and various severe health issues.
  • - Pituitary adenomas (PAs) show a wide range of clinical and biological characteristics and can behave aggressively, making them challenging to classify and treat effectively over time.
  • - The latest WHO Classification categorizes GH-secreting PAs into different types based on hormonal features, but more research is needed to better understand their behavior and improve treatment strategies through precision medicine.
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 The endoscopic endonasal route has demonstrated to be the approach of choice for a large majority of clival chordomas (CCs). However, its results in elderly patients are under-evaluated in the literature. The aim of this study is to assess the surgical outcome for these patients, determining the factors associated with a larger tumor resection in this population.

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