Publications by authors named "D Matthew Hartwig"
Background: Malignant hypercalcemia is usually caused by osteolytic processes of metastases, production of parathormone-related peptide, or secretion of 1,25-dihydroxyvitamin D. Ectopic PTH (parathyroid hormone) production by malignancy is very unusual.
Methods: Case report and review of the literature.
Article Synopsis
- - The study investigates antibiotic resistance and biofilm formation in Klebsiella pneumoniae strains from a university hospital in Pelotas, Brazil, highlighting the strains' persistence in hospital settings.
- - Out of 28 K. pneumoniae isolates, a significant majority (96.42%) strongly formed biofilms, with 64.29% classified as multidrug-resistant (MDR), revealing a concerning level of antibiotic resistance.
- - Genetic analysis showed 18 unique clones, indicating that the same strains circulated in different samples over two years, underscoring the need for improved control measures and disinfection protocols in hospital environments.
Intensive care unit cardiac arrest among very elderly critically ill patients - is cardiopulmonary resuscitation justified?
Scand J Trauma Resusc Emerg Med
September 2024
Introduction: The proportion of very elderly patients in the intensive care unit (ICU) is expected to rise. Furthermore, patients are likely more prone to suffer a cardiac arrest (CA) event within the ICU. The occurrence of intensive care unit cardiac arrest (ICU-CA) is associated with high mortality.
View Article and Find Full Text PDFAntibiofilm effect of biogenic silver nanoparticle alone and combined with polymyxin B against carbapenem-resistant Acinetobacter baumannii.
Braz J Microbiol
September 2024
Acinetobacter baumannii is a bacteria associated with nosocomial infections and outbreaks, difficult to control due to its antibiotic resistance, ability to survive in adverse conditions, and biofilm formation adhering to biotic and abiotic surfaces. Therefore, this study aimed to evaluate the antibiofilm activity of biogenic silver nanoparticle (Bio-AgNP) and polymyxin B alone and combined in biofilms formed by isolates of carbapenem-resistant A. baumannii (CR-Ab).
View Article and Find Full Text PDFAims: Currently, immunoinformatic approaches have shown promise in rapidly and cost-effectively identifying new antigens from the Leptospira proteome. Chimeric multiepitope proteins offer a strategy with significant potential for implementation in diagnosis and vaccines development.
Methods And Results: In this study, we detail the immunoinformatic analyses and design of a new recombinant chimeric protein constructed with epitopes identified from the sequences of ErpY-like and LemA proteins, previously identified as potential antigens for controlling leptospirosis.