Happy-Productive worker thesis: The role of work characteristics, gender, and age.

Happy-productive worker thesis (HPWT) research predicts four configurations depending on well-being and performance levels, one synergistic and three antagonists; however, there has been some discrepancy in the expected results of HPWT, as there are some inclusive results about the specific characteristics that lead to each one of the predicted groups. In this study, we face these discrepancies using a three-configuration model that is more realistic in the organizational context, and exploring how work characteristics, gender, and age can predict workers' membership in such configurations. We performed multinomial logistic regressions using a sample of 504 Colombian workers and their supervisors from different economic sectors.

Dual Inhibition of Mast Cells and Thymic Stromal Lymphopoietin Using a Novel Bispecific Antibody, CDX-622.

Background: Mast cells (MCs) respond to an array of allergens that drive allergic and inflammatory diseases. Stem cell factor (SCF), the ligand for the receptor KIT, is required for MC survival and function. Thymic stromal lymphopoietin (TSLP) is an alarmin that promotes Type 2 inflammation in asthma and other inflammatory diseases.

Untreated Vestibular Schwannoma: Analysis of the Determinants of Growth.

The growth rate of sporadic VS varies considerably, posing challenges for consistent clinical management. This systematic review examines data on factors associated with VS growth, following a protocol registered in the PROSPERO database. The analysis reveals that key predictors of tumor growth include tumor location, initial size, and specific clinical symptoms such as hearing loss and imbalance.

Synergistic Effects of PARP Inhibition and Cholesterol Biosynthesis Pathway Modulation.

Unlabelled: An in-depth multiomic molecular characterization of PARP inhibitors revealed a distinct poly-pharmacology of niraparib (Zejula) mediated by its interaction with lanosterol synthase (LSS), which is not observed with other PARP inhibitors. Niraparib, in a similar way to the LSS inhibitor Ro-48-8071, induced activation of the 24,25-epoxysterol shunt pathway, which is a regulatory signaling branch of the cholesterol biosynthesis pathway. Interestingly, the combination of an LSS inhibitor with a PARP inhibitor that does not bind to LSS, such as olaparib, had an additive effect on killing cancer cells to levels comparable with niraparib as a single agent.

Honey Added to Yogurt with Bifidobacterium animalis subsp. lactis DN-173 010/CNCM I-2494 Supports Probiotic Enrichment but Does Not Reduce Intestinal Transit Time in Healthy Adults: A Randomized, Controlled, Crossover Trial.

Background: Honey improves probiotic survival in vitro. However, if this effect translates to humans has not been investigated.

Objectives: We aimed to determine effects of honey plus yogurt containing the probiotic Bifidobacterium animalis subsp.