Stability of a second-generation cephalosporin veterinary mastitis formulation after electron beam irradiation.

This study focused on the chemical stability of the cephalosporin (6R, 7R)-7-(1-pentafluorophenoxyacetamido)-3-[2-(5-methyl-1,3,4-thiodiazolyl)thiomethyl]-Delta(3)-cephem-4-carboxylic acid, sodium salt (cephem 1) formulation after electron beam (e-beam) irradiation. The cephem 1 concentrations of samples irradiated at 5, 10, and 15 kilograys for glass vials and low-density polyethylene (LDPE) cannula syringes were not statistically different from the concentrations of the nonirradiated control samples. Samples from each irradiation dose stored in controlled-temperature chambers at 5 degrees C and 30 degrees C for 24 months did not show any concentration changes within statistical limits compared with the nontreated samples.

Effect of O-(beta-hydroxyethyl)-rutoside on the glucose metabolism of cultured human varicose saphenous veins.

The flavonoid O-(beta-hydroxyethyl)-rutoside appears to have a slight inhibitory action upon the oxidative metabolism and lactate production of culured human varicose saphenous veins. The possibility that exogenous glucose would be utilized in other metabolic pathways is discussed.

Free amino acids in normal and varicose human saphenous veins.

An increase in the activity of lysosomal enzymes in varicose veins has been suggested in the literature, as well as an alteration of collagen fibrils situated near muscle cells. In view of these results, we have compared the free amino acid contents of varicose veins with those of healthy veins removed few hours after death. The amino acid analyses of extracts have shown that the varicose vein appears to contain about 2.