Predicting adaptive immune receptor specificities by machine learning is a data generation problem.

Determining the specificity of adaptive immune receptors-B cell receptors (BCRs), their secreted form antibodies, and T cell receptors (TCRs)-is critical for understanding immune responses and advancing immunotherapy and drug discovery. Immune receptors exhibit extensive diversity in their variable domains, enabling them to interact with a plethora of antigens. Despite the significant progress made by AI tools such as AlphaFold in predicting protein structures, challenges remain in accurately modeling the structure and specificity of immune receptors, primarily due to the limited availability of high-quality crystal structures and the complexity of immune receptor-antigen interactions.

The design and evaluation of a bone health teaching module for secondary school students in NSW, Australia.

Issue Addressed: The growing prevalence of osteoporosis requires preventative management starting from an early age as peak bone mass is typically reached by age 30. However, current Australian adolescents are not adequately addressing key osteoprotective factors. Alarmingly, around 17% have insufficient vitamin D levels, 55% consume insufficient dietary calcium, and 79% are insufficiently active.

Nurses' Voices in Media: Strategies for Chief Nursing Officers.

Nurses comprise the largest group of health professionals yet are underrepresented in health news media, depriving the public of important perspectives on health and healthcare and undermining the public's perceptions of nurses as experts. The George Washington University School of Nursing's Center for Health Policy and Media Engagement partnered with the American Organization for Nursing Leadership to invite a small group of chief nursing officers to participate in a workshop aimed at building an organization-specific strategy for sharing nurses' expertise with the public through media engagement. Participants completed a preworkshop survey, participated in two 4-hour workshops to explore the factors that contribute to nurses' invisibility as media sources, and developed a strategic plan for ensuring that their healthcare organizations are able to recognize and share their nurses' expertise with media.