Vaccination with recombinant adenoviruses expressing Ebola virus glycoprotein elicits protection in the interferon alpha/beta receptor knock-out mouse.

The resistance of adult immunocompetent mice to infection with ebolaviruses has led to the development of alternative small animal models that utilise immunodeficient mice, for example the interferon α/β receptor knock-out mouse (IFNR(-/-)). IFNR(-/-) mice have been shown to be susceptible to infection with ebolaviruses by multiple routes but it is not known if this murine model is suitable for testing therapeutics that rely on the generation of an immune response for efficacy. We have tested recombinant adenovirus vectors for their ability to protect IFNR(-/-) mice from challenge with Ebola virus and have analysed the humoral response generated after immunisation.

[-The clinical use of the cuffed oropharyngeal airway (COPA)-].

Objective: To assess the performance of the COPA device during general anaesthesia.

Study Design: Prospective, clinical, open study.

Patients: Eighty patients scheduled for short elective surgical procedures under general anaesthesia not requiring tracheal intubation.

[Acute postoperative respiratory insufficiency of uncommon cause].

We report a case of acute respiratory distress which occurred three days after orthopaedic surgery and which led to the diagnosis of spontaneous rupture of the oesophagus (Boerhaave syndrome). The unusual nature of the signs delayed diagnosis.