Cerebral blood flow patterns in preterm and term neonates assessed with pseudo-continuous arterial spin labeling perfusion MRI.

In preterm (PT) infants, regional cerebral blood flow (CBF) disturbances may predispose to abnormal brain maturation even without overt brain injury. Therefore, it would be informative to determine the spatial distribution of grey matter (GM) CBF in PT and full-term (FT) newborns at term-equivalent age (TEA) and to assess the relationship between the features of the CBF pattern and both prematurity and prematurity-related brain lesions. In this prospective study, we obtained measures of CBF in 66 PT (51 without and 15 with prematurity-related brain lesions) and 38 FT newborns through pseudo-continuous arterial spin labeling (pCASL) MRI acquired at TEA.

Pathophysiology of multiple sclerosis damage and repair: Linking cerebral hypoperfusion to the development of irreversible tissue loss in multiple sclerosis using magnetic resonance imaging.

Background And Purpose: Reduced cerebral perfusion has been observed in multiple sclerosis (MS) and may contribute to tissue loss both acutely and chronically. Here, we test the hypothesis that hypoperfusion occurs in MS and relates to the presence of irreversible tissue damage.

Methods: In 91 patients with relapsing MS and 26 healthy controls (HC), gray matter (GM) cerebral blood flow (CBF) was assessed using pulsed arterial spin labeling.

Hemispheric functional segregation facilitates target detection during sustained visuospatial attention.

Visuospatial attention is strongly lateralized, with the right hemisphere commonly exhibiting stronger activation and connectivity patterns than the left hemisphere during attentive processes. However, whether such asymmetry influences inter-hemispheric information transfer and behavioral performance is not known. Here we used a region of interest (ROI) and network-based approach to determine steady-state fMRI functional connectivity (FC) in the whole cerebral cortex during a leftward/rightward covert visuospatial attention task.

Microwave techniques for electron cyclotron resonance plasma diagnostics.

This paper reviews the main microwave diagnostic techniques and tools adopted in electron cyclotron resonance (ECR) (and others) ion source laboratories, with a special focus on techniques and instruments developed at INFN-LNS. Along with the tools used for optimization of microwave launching (power monitors, spectral analysis, and network analyzers), this paper deals, in particular, with more recent devices on-purpose developed to perform in-plasma analysis, such as absolute density measurements and density profiles retrieval. Among these, the first example of microwave interferometry for ECR compact machines (the VESPRI interferometer at INFN-LNS) will be briefly discussed, in combination with microwave polarimetric techniques based on Faraday rotation detection.