Publications by authors named "D Martak"
Background: ESBL-producing Enterobacterales (ESBL-PE) are highly prevalent in long-term healthcare (LTCF) settings. In order to estimate the acquisition rate of ESBL-producing Escherichia coli and Klebsiella pneumoniae in LTCF settings and identify clinical and environmental risk factors, a multicentric, prospective cohort study was conducted in six LTCFs in Germany, France, Spain and the Netherlands.
Methods: Longitudinal screening of residents was performed over 32 weeks, collecting epidemiological and clinical data and environmental samples.
Article Synopsis
- * Human activities like sewage disposal, manure application, and industrial effluents introduce antibiotic-resistant bacteria (ARB) and genes (ARGs) into ecosystems, with varying impacts based on the country's income level, sanitation infrastructure, and farming practices.
- * To combat AMR, it's crucial to enhance wastewater treatment facilities, reduce antibiotic usage, opt for safer antibiotics, and regulate pharmaceutical waste, particularly emphasizing disparities between high-income (HICs) and low/middle-income countries (LMICs).
Objectives: To determine prevalence, incidence, and factors associated with Pseudomonas aeruginosa (PA) intestinal carriage in residents of long-term care facilities (LTCFs) and to understand the population structure of this pathogen in LTCFs from two European countries.
Methods: We assessed the prevalence of PA intestinal carriage and the incidence of acquisition by collecting fecal samples from 403 residents of 20 LTCFs. We collected 289 environmental samples from sinks and drinking water.
Article Synopsis
- - The study investigates the presence and behavior of antibiotic-resistant opportunistic pathogens in floodplain ecosystems in Eastern France, focusing on various strains of E. coli and Klebsiella pneumoniae.
- - Monthly sampling over a year revealed that the majority of E. coli isolates in the floodplain were likely human-derived, with contamination primarily occurring during periods of high water flow, which aids in pathogen dispersal.
- - Isolated ecosystems, especially nutrient-rich wetlands, could serve as reservoirs for these pathogens, as E. coli can survive for months during low water flow, showing that antibiotic resistance does not hinder its survival in less disturbed environments.
Background: Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) is a major cause of infections worldwide. An understanding of the reservoirs and modes of transmission of these pathogens is essential, to tackle their increasing frequency.
Objectives: We investigated the contributions of various compartments (humans, animals, environment), to human colonization or infection with ESBL-Ec over a 3 year period, on an island.