Do we need urine drug screens in opioid addiction treatment: An observational study on self-report versus urine drug screens.

Background: The substance use crisis continues to progress. Medication for Opioid Use Disorder (MOUD) are prescribed to reduce opioid use and related harms; however, many individuals continue to use substances while on treatment. The objective of this study was to describe the temporal and demographic trends of the agreement between self-reported and urine tested substances.

The potential regulation of the miR-17-92a cluster by miR-21.

MicroRNAs (miRNA,miRs) are small noncoding RNAs that are ubiquitously expressed in all mammalian cells. Their primary function is the regulation of nascent RNA transcripts by direct binding to regions on the target. There is now exciting data to suggest that these miRNAs can bind to other miRNAs, and this may have a broader impact on gene regulation in disease states.

Patient and Healthcare Provider Experience With Rheumatoid Arthritis in Northern Ontario, Canada: A Qualitative Descriptive Study.

Background: Rheumatoid arthritis (RA) is a disabling common chronic inflammatory joint disease. In Ontario, the burden is higher in those aged 65 and older, in females, and in northern communities. This study examined patient disease impact and healthcare provider access and satisfaction as well as provider satisfaction, patient experience and educational suggestions.

Response of the nephron arterial network and its interactions to acute hypertension: a simulation.

We simulated the dynamics of a group of 10 nephrons supplied from an arterial network and subjected to acute increases in blood pressure. Arterial lengths and topology were based on measurements of a vascular cast. The model builds on a previous version exercised at a single blood pressure with 2 additional features: pressure diuresis and the effect of blood pressure on efferent arteriolar vascular resistance.

A Swing-Assist Controller for Enhancing Knee Flexion in a Semi-Powered Transfemoral Prosthesis.

This work proposes a new swing controller for semi-powered low impedance transfemoral prostheses that resolves the issue of potentially competing inputs between artificial assistive power and user-sourced power. Rather than add power as an exogeneous input, the control approach uses power to modify the homogeneous portion of the shank dynamics, and therefore need not construct or curate an input that is coordinated with user input. The implemented controller requires a single control parameter at a given walking speed, where the value of that parameter is a function of walking speed, as determined by an adaptive algorithm, such that peak knee angles are commensurate with walking-speed-dependent behaviors of individuals without any negative gait pathologies.