Publications by authors named "D Manson"
Children with compromised immune systems, whether due to primary or secondary immunodeficiencies, are susceptible to a broad spectrum of acute intrathoracic pathologies. These include infections, pulmonary edema, and malignancies. Pulmonary issues are common and perilous in this population, necessitating prompt and precise diagnosis for effective management.
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- - Quorum sensing (QS) is a communication system used by bacteria to coordinate behaviors based on their population density, using chemical signals and specific receptors, particularly in Gram-negative bacteria.
- - Disrupting QS is a promising therapeutic strategy against pathogenic bacteria, and this study examines benzaldehyde derivatives for their ability to inhibit the LasR and RhlR QS receptors.
- - The study finds that many benzaldehyde derivatives can inhibit LasR or RhlR activation without being toxic, with -vanillin emerging as the most effective compound that specifically interacts with RhlR.
Context: A quarter of palliative care (PC) clinicians' consultations are now requested from the intensive care unit (ICU). Despite this high usage, a standardized set of quality metrics for PC delivery in the ICU does not exist.
Objectives: To explore PC clinicians' views on how to best measure quality of care delivery in their role as a consultant in the ICU setting.
Article Synopsis
- - Quorum sensing (QS) is a process that allows bacteria to communicate and adapt based on their population density, primarily using acyl L-homoserine lactone signals and LuxR-type receptors in Gram-negative bacteria.
- - Disrupting QS can be a therapeutic strategy against pathogenic bacteria, and previous research identified natural products like salicylic acid and cinnamaldehyde as potential QS inhibitors, although the mechanisms remain unclear.
- - The study tests various benzaldehyde derivatives for their ability to inhibit QS receptors LasR and RhlR, finding that vanillin is particularly effective at selectively blocking RhlR without causing toxicity at lower concentrations.