Role of oral health literacy in demand for oral healthcare services for missing teeth replacement among dental patients visiting a dental teaching hospital in India.

Aims: To assess the role of oral health literacy (OHL) in demand for oral healthcare services for missing teeth replacement among adult patients who are visiting the outpatient department of a teaching hospital, Andhra Pradesh, India.

Settings And Design: This cross-sectional study was conducted in a dental teaching institute, Andhra Pradesh, southern part of India.

Materials And Methods: Based on the inclusion and exclusion criteria, a sample of adult participants was selected through systematic random method from the patients who visited the outpatient department.

Co-gasification of blast furnace dust with petcoke for sustainable waste management.

This study employed a lab-scale fluidized bed steam gasification setup to perform the co-gasification experiments with blast furnace dust (BFD) and petcoke (PC) - wastes from the steel and refining industries, respectively. Multiple experiments were conducted at the optimized conditions to decipher the effects of the mineralogical content of the feed samples on the gasification performance parameters. With the addition of iron and zinc-abundant BFD sample to PC, an effective enhancement in the ability of the gasifier to produce hydrogen-rich synthesis gas was observed, attributed to an increase in surface active sites for gasification reactivity.

The Correlations between Volume Loss of Temporal and Subcortical Functional Subregions and Cognitive Impairment at Various Stages of Cognitive Decline.

Background: The relationship between subregion atrophy in the entire temporal lobe and subcortical nuclei and cognitive decline at various stages of Alzheimer's disease (AD) is unclear.

Methods: We selected 711 participants from the AD Neuroimaging Initiative (ADNI) database, which included 195 cases of cognitively normal (CN), 271 cases of early Mild cognitive impairment (MCI) (EMCI), 132 cases of late MCI (LMCI), and 113 cases of AD. we looked at how subregion atrophy in the temporal lobe and subcortical nuclei correlated with cognition at different stages of AD.

Discovery of an Efficacious RET PROTAC Degrader with Enhanced Antiproliferative Activity against Resistant Cancer Cells Harboring RET Solvent-Front Mutations.

Rearranged during transfection (RET) kinase is a validated therapeutic target for various cancers characterized by RET alterations. Although two selective RET inhibitors, selpercatinib and pralsetinib, have been approved by the FDA, acquired resistance through solvent-front mutations has been identified rapidly. Developing proteolysis targeting chimera (PROTAC) targeting RET mutations offers a promising strategy to combat drug resistance.