Publications by authors named "D Manno"
Pregnancy and neonatal outcomes in Eastern Democratic Republic of the Congo: a systematic review.
Front Glob Womens Health
December 2024
Background: Conflict is known to impact maternal and neonatal health in Eastern Democratic Republic of the Congo (DRC), an area of longstanding insecurity. We conducted a systematic review on pregnancy and neonatal outcomes in this region to provide a comprehensive overview of maternal and neonatal outcomes over a 20-year period.
Methods: We systematically searched databases, such as Medline, EMBASE, Global Health, ClinicalTrials.
rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo are WHO-prequalified vaccination regimens against Ebola virus disease (EVD). Challenges associated with measuring long-term clinical protection warrant the evaluation of immune response kinetics after vaccination.
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- * While fewer than 1% of non-pregnant participants faced serious adverse events (SAEs), 30.4% of pregnant women experienced SAEs, primarily due to caesarean sections, but none were linked to the vaccine.
- * Among 1169 tracked pregnancies, there were some miscarriages, stillbirths, and low birth weights, yet the vaccine was generally well-tolerated, with a high uptake rate of 75.1%, prompting calls for more controlled trials for further insights.
Magnetic nanocomposites (MNC) are promising theranostic platforms with tunable physicochemical properties allowing for remote drug delivery and multimodal imaging. Here, we developed doxorubicin-loaded FeO-Au MNC (DOX-MNC) using electron beam physical vapor deposition (EB-PVD) in combination with magneto-mechanochemical synthesis to assess their antitumor effect on Walker-256 carcinosarcoma under the influence of a constant magnetic (CMF) and electromagnetic field (EMF) by comparing tumor growth kinetics, magnetic resonance imaging (MRI) scans and electron spin resonance (ESR) spectra. Transmission (TEM) and scanning electron microscopy (SEM) confirmed the formation of spherical magnetite nanoparticles with a discontinuous gold coating that did not significantly affect the ferromagnetic properties of MNC, as measured by vibrating-sample magnetometry (VSM).
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- This study monitored long-term safety data from participants who received the Ebola vaccines Ad26.ZEBOV and/or MVA-BN-Filo across 15 sites in seven countries.
- A total of 614 adults were followed for 60 months post-vaccination, revealing that 8% experienced at least one serious adverse event (SAE), with a specific incidence rate calculated.
- The study found no major safety concerns, as there were no deaths or life-threatening SAEs, and only one SAE was related to the vaccines, indicating their long-term safety.