Serotonin 1A Receptors Modulate Serotonin 2A Receptor-Mediated Behavioral Effects of 5-Methoxy-,-dimethyltryptamine Analogs in Mice.

5-methoxy-,-dimethyltrytpamine (5-MeO-DMT) analogs are used as recreational drugs, but they are also being developed as potential medicines, warranting further investigation into their pharmacology. Here, we investigated the neuropharmacology of 5-MeO-DMT and several of its -alkyl, -allyl, and 2-methyl analogs, with three major aims: 1) to determine in vitro receptor profiles for the compounds, 2) to characterize in vitro functional activities at serotonin (5-HT) 2A receptors (5-HT) and 1A receptors (5-HT), and 3) to examine the influence of 5-HT on 5-HT-mediated psychedelic-like effects in the mouse head twitch response (HTR) model. In vitro receptor binding and functional assays showed that all 5-MeO-DMT analogs bind with high affinity and activate multiple targets (e.

Bis(4-acetoxy--ethyl---propyl-tryptammonium) fumarate-fumaric acid (1/1).

The solid-state structure of the title salt/adduct (systemic name: bis-{[2-(4-acet-yloxy-1-indol-3-yl)eth-yl](eth-yl)propyl-aza-nium} but-2-enedioate-()-butenedioic acid (1/1)), 2CHNO ·CHO ·CHO, was determined by single-crystal X-ray diffraction. The asymmetric unit consists of a singly protonated tryptammonium cation, one half of a fumarate dianion and one half of a fumaric acid mol-ecule. In the crystal, the ions and mol-ecules are linked together in infinite chains propagating along [001] through a series of N-H⋯O and O-H⋯O hydrogen bonds.

3,5-Lutidine penta-aqua sulfate complexes of first-row transition metals: [(3,5-lutidine)(HO)]SO, with = Mn, Co, Ni, and Zn.

The reactions of MnSO·HO, CoSO·7HO, NiSO·6HO and ZnSO·7HO with 3,5-lutidine (3,5-di-methyl-pyridine) yield crystals of penta-aqua-(3,5-di-methyl-pyridine-κ)manganese(II) sulfate, [Mn(CHN)(HO)]SO, (), penta-aqua-(3,5-di-methyl-pyridine-κ)cobalt(II) sulfate, [Co(CHN)(HO)]SO, (), penta-aqua-(3,5-di-methyl-pyridine-κ)nickel(II) sulfate, [Ni(CHN)(HO)]SO, (), and penta-aqua-(3,5-di-methyl-pyridine-κ)zinc(II) sulfate, [Zn(CHN)(HO)]SO, (), which were characterized by single-crystal X-ray diffraction. The four crystals are isostructural, demonstrating near identical unit-cell parameters and atomic positions. The metal atoms are all octa-hedrally coordinated, with one lutidine ligand and five water ligands.

-Methyl-serotonin hydrogen oxalate.

The solid-state structure of -methyl-serotonin {systematic name: [2-(5-hy-droxy-1-indol-3-yl)eth-yl](meth-yl)aza-nium hydrogen oxalate}, CHNO·CHO , is reported. The structure possesses a singly protonated -methylserotonin cation and one hydrogen oxalate anion in the asymmetric unit. In the crystal, the mol-ecules are linked by N-H⋯O and O-H⋯O hydrogen bonds into a three-dimensional network.