Publications by authors named "D Manganaro"
Background & Aims: WNT signaling is central to spatial tissue arrangement and regulating stem cell activity, and it represents the hallmark of gastrointestinal cancers. Although its role in driving intestinal tumors is well characterized, WNT's role in gastric tumorigenesis remains elusive.
Methods: We have developed mouse models to control the specific expression of an oncogenic form of β-catenin (CTNNB1) in combination with MYC activation in Lgr5 cells of the gastric antrum.
Article Synopsis
- * A specific vascular barrier in the brain, known as the choroid plexus (PVB), responds to intestinal inflammation, which can lead to its closure due to the activation of a signaling pathway (Wnt/β-catenin).
- * This closure of the PVB may contribute to cognitive problems and anxiety, highlighting a potential link between gut health and mental health in IBD patients.
BAP1 is mutated or deleted in many cancer types, including mesothelioma, uveal melanoma, and cholangiocarcinoma. It is the catalytic subunit of the PR-DUB complex, which removes PRC1-mediated H2AK119ub1, essential for maintaining transcriptional repression. However, the precise relationship between BAP1 and Polycombs remains elusive.
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