Publications by authors named "D Mametja"
Background: Tuberculosis remains an important clinical and public health issue in South Africa, which has one of the highest tuberculosis burdens in the world. We aimed to estimate the burden of bacteriologically confirmed pulmonary tuberculosis among people aged 15 years or older in South Africa.
Methods: This multistage, cluster-based, cross-sectional survey included eligible residents (age ≥15 years, who had slept in a house for ≥10 nights in the preceding 2 weeks) in 110 clusters nationally (cluster size of 500 people; selected by probability proportional-to-population size sampling).
Examining the cost of community-based tuberculosis treatment in South Africa.
Int J Tuberc Lung Dis
June 2020
While South Africa has improved access to tuberculosis (TB) treatment and care, the 2015 treatment success rate for multidrug-resistant TB (MDR-TB) remains low, at 55%. Community-based TB treatment and care improves patient retention compared to the standard of care alone. To assess the cost of a USAID-funded community-based TB model in Nelson Mandela Bay Health District (NMBHD), Eastern Cape Province, South Africa compared to the national standard of care alone.
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- The post-2015 End TB Strategy aims to cut tuberculosis incidence by 50% and mortality by 75% by 2025, focusing on strategies in China, India, and South Africa to achieve these goals.
- Researchers assessed various intervention scenarios and their costs, finding that expanding tuberculosis services could lead to significant health improvements and even cost savings in India and China, despite high initial funding needs.
- Overall, the expansion of tuberculosis services appears to be cost-effective, offering substantial health benefits; however, further research is needed to identify the best intervention strategies for each country.
Background: South Africa has a large burden of extensively drug-resistant tuberculosis (XDR-TB); only 15% of XDR-TB patients have successful outcomes.
Objective: To describe the safety and effectiveness of bedaquiline (BDQ) in the South African BDQ Clinical Access Programme.
Design: An interim cohort analysis.
Background: South Africa has the highest incidence of tuberculosis in the world, largely resulting from a high population prevalence of HIV infection. We investigated the incidence of microbiologically confirmed pulmonary tuberculosis, and new cases of pulmonary tuberculosis registered for treatment, nationally and provincially in South Africa from 2004 to 2012, during which time there were changes in antiretroviral therapy (ART) coverage among individuals with HIV infection.
Methods: We identified cases of microbiologically confirmed pulmonary tuberculosis from 2004 to 2012 from the National Health Laboratory Service Corporate Data Warehouse.