Canthaxanthin ameliorates atopic dermatitis in mice by suppressing Th2 immune response.

Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disorder characterized by intense pruritus and complex immunopathogenic mechanisms. Recent evidence has highlighted the critical link between dysregulated intestinal microecology and altered immune responses in AD progression. As essential components of the intestinal microenvironment, metabolites play pivotal roles in various physiological processes.

Eight-electron Pt/Cu superatom encapsulating three "electron-donating" hydrides.

Hydrides in metal complexes or nanoclusters are typically viewed as electron-withdrawing. Several recent reports have demonstrated the emergence of "electron-donating" hydrides in tailoring the structure, electronic structure, and reactivity of metal nanoclusters. However, the number of such hydrides included in each cluster kernel is limited to one or two.

β-Catenin mediated TAM phenotype promotes pancreatic cancer metastasis via the OSM/STAT3/LOXL2 axis.

Pancreatic ductal adenocarcinoma (PDAC) is characterized by its aggressive nature and dismal prognosis, largely attributed to its unique tumor microenvironment. However, the molecular mechanisms by which tumor-associated macrophages (TAMs) promote PDAC progression, particularly the role of β-catenin signaling in regulating TAM phenotype and function, remain incompletely understood. Initially, we performed comprehensive analyses of RNA-seq and single-cell RNA-seq (scRNA-seq) datasets to investigate OSM and LOXL2 expression patterns in PDAC.

A low-temperature-tolerant and non-flammable cellulose/HEC/PVA eutectogel for flexible asymmetric supercapacitors.

Asymmetric supercapacitors (ASCs), which combine the advantages of electric double-layer capacitors and pseudocapacitors, have attracted more and more research interest. However, the performance of water-based ASCs often faces the challenge of electrolyte freezing at low temperatures. To resolve the problem, a ternary deep eutectic solvent (DES) with an eutectic point of less than -100 °C was first prepared.