Phosphorus addition mitigates the combined negative effects of high temperature and nitrogen stress on corals.

Global warming and imbalances in nitrogen (N)-phosphorus (P) ratios due to increased human activity have had significant impacts on coral reef ecosystems. However, the underlying mechanisms of these impacts remain poorly understood. In this study, a controlled experiment was conducted on Acropora hyacinthus treated with different P concentrations at high temperature (30 °C) and high N level (9 μM nitrate), which was analyzed in terms of physical observations and physiological indices, as well as photosynthetic activity and fatty acid composition.

Preventive hyperbaric oxygen therapy improves acute graft-versus-host disease by activating the Nrf2/HO-1 pathway.

Background: Hyperbaric oxygen therapy (HBOT) has been confirmed as an effective and economical therapeutic modality for treating hemorrhagic cystitis (HC), whether induced by infection or acute graft-versus-host disease (aGVHD), in transplant recipients. However, its potential benefits in treating aGVHD remain largely unknown. This study explored the effects of HBOT on aGVHD and its underlying mechanisms.

Association of branched-chain amino acids with major depressive disorder: A bidirectional Mendelian randomization study.

Background: Recent studies have linked branched-chain amino acids (BCAAs) metabolism with the risk of major depressive disorder (MDD). However, it is unclear whether associations of plasma BCAA levels with MDD are causal or driven by reverse causality.

Methods: Mendelian randomization (MR) was used to investigate the causal association of genetically determined BCAA levels with the risk of MDD.

Exploring mechanisms of britannin against colorectal cancer based on experimentally validated network pharmacology.

Britannin is an active compound derived from Inula japonica Thunb. that possess a wide range of pharmacological activities. However, the mechanism underlying its influence on colorectal cancer (CRC) is not clear.

Administration of Porphyromonas gingivalis in pregnant mice enhances glycolysis and histone lactylation/ADAM17 leading to cleft palate in offspring.

Periodontal disease is a risk factor for many systemic diseases such as Alzheimer's disease and adverse pregnancy outcomes. Cleft palate (CP), the most common congenital craniofacial defect, has a multifaceted etiology influenced by complex genetic and environmental risk factors such as maternal bacterial or virus infection. A prior case-control study revealed a surprisingly strong association between maternal periodontal disease and CP in offspring.