[3H]Tyramine uptake by rat liver slices.

Rat liver slices were employed as experimental model to characterise the system involved in the transport process which participates in liver tyramine uptake. The uptake of 0.4 micromol l-1of [3H]tyramine by rat liver slices was linear from 5 min up to the end of incubation.

[Effect of treatment with dexamethasone on cardiovascular responses of adrenergic agents].

Cardiovascular responses to several agents should be modified by glucocorticoid administration in the rat. We investigate the response to adrenergic agonists such as phenylephrine, noradrenaline, clonidine and isoproterenol and ganglionic blocking agent such as hexamethonium in conscious rats treated during 7 days with dexamethasone. Wistar rats were treated with either Dex (150 micrograms daily x 7 days, p.

Cholestasis as a liver protective factor in paracetamol acute overdose.

1. The effect of paracetamol overdoses on its disposition was investigated in cholestatic rats. 2.

Studies of tyramine transfer and metabolism using an in vitro intestinal preparation.

The duodenal transfer and metabolism of [3H]tyramine from sacs and perfused segments of rat intestine were determined. In sacs, a linear relationship between the steady-state transfer rate of total tritium and the initial mucosal tyramine concentration was observed, suggesting that the clearance is the same at different concentrations. In duodenal perfusions, there was no significant difference in the amount of total tritium removed between control and everted tissues, whether the flow was 0.

Accumulation of 3H-(+/-)-noradrenaline by isolated rat liver cells.

Using hepatocytes isolated by collagenase perfusion, we studied the accumulation of 3H-noradrenaline. Cells incubated during 15 min in the presence of 0.4 mumol/l 3H-noradrenaline (without inhibition of noradrenaline metabolism) accumulated 8.